Course Title : Fine Synthetic Chemistry

Code 10H834
Course Year Master and Doctor Course
Term
Class day & Period Wed 2nd
Location A2-308
Credits
Restriction No Restriction
Lecture Form(s) Lecture
Language Japanese
Instructor Masahiro Murakami, Tomoya Miura,

Course Description

Grading

Paper test

Course Goals

Course Topics

Theme Class number of times Description
principle and examples of selective reaction 4 1. Hammond Postulate and Curtin-Hammett Principle 2. Chemo- and Stereoselectivities of Hydride Reduction 3. Cram Model and Felkin-Anh Model (Basic Rule) 4. Cram Model and Felkin-Anh Model (Application)
total synthesis of natural products 6 5. (+)-Himbacine (Chackalamannil 1999) (key point: Diels-Alder) 6. ZK-EPO (Schering AG 2006) (key point: Macrolactonization) 7. (-)-Dactylolide (McLeod 2006) (key point: Ireland-Claisen) 8. (-)-Scopadulcic Acid (Overman 1999) (key point: Heck Reaction) 9. (+)-Paniculatine (Sha 1999) (key point: Radical Cyclization) 10. Hirsutine (Tietze 1999) (key point: Domino Reaction)
1 11. Confirmation of achievement degree: The synthesis of target molecules using selective reaction is proposed by students, and then, we discuss it.

Textbook

nothing

Textbook(supplemental)

Organic Synthesis Workbook II (Wiley-VCH), Organic Synthesis Workbook III (Wiley-VCH)

Prerequisite(s)

Independent Study Outside of Class

Web Sites

Additional Information