Course Title : Organic Chemistry II (Fundamental Chemistry)

Code 72080
Course Year 3rd year
Class day & Period
Credits 2
Lecture Form(s)
Language Japanese
Instructor ,

Course Description

This course is designed for student who already learned basic organic chemistry. This course consists of three major parts. The first part concerns stereochemistry of organic compounds and reactions. The second part focuses on the reaction of saturated organic compounds bearing leaving groups. Nuceophilic substitution and elimination are involved in this part. The third part gives the details of the reactivities of unsaturated organic compounds bearing p-electrons such as alkenes, enols, enolates, and aromatic compounds.


Course Goals

Course Topics

Theme Class number of times Description
Stereochemistry 2 Enantiomers; Diastereomers; Chiral compounds devoid of chiral centers; Symmetry, Optical resolution (Chapter 14)
Nucleophilic Substitution 3 Mechanism; SN1 and SN2 reactions; Leaving group; Nucleophiles; Elimination and Rearrangement (Chapter 15)
Elimination 2 Effect of Nucleophiles on Elimination and Substitution; E1 and E2 Elimination; Role of leaving group; Stereochemistry of elimination; E1cB reaction (Chapter 17)
Electrophilic Addition to Alkenes 3 Bromination, Epoxidation; Regio- and stereochemistry of electrophilic addition; addition to conjugated dienes; Mechanism, Halolactonization (Chapter 19)
Formation and Reaction of Enols and Enolate 2 Keto-enol Tautomerization; Acid- and base-catalyzed enolization; Stable enols; Reactions involving enols and enolates as intermediates; Stable enolate equivalents; Reaction at the oxygen atoms of enol and enolate; Reactions of enol ethers (Chapter 20)
Aromatic Electrophilic Substitution 2 Electrophilic substitution of benzene, phenol, and anilines; ortho/para and meta preferences (Chapter 21)
Examination 1


Organic Chemistry (Second Edition; Clayden, Greeves, Warren; Oxford University Press: 2012)



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